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عمومی::
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In some cases, the antibody has a ratio of antibody binding to the phosphorylated peptide of SEQ-ID-NO:8 to antibody binding to the non-phosphorylated peptide of SEQ-ID-NO:69 of at least about 40.
[0042] FIG. 3 illustrates the selective binding affinity of several anti-pS413-Tau antibodies for phosphorylated peptide PD17P, relative to non-phosphorylated peptide PD17, in accordance with some embodiments of the disclosure.
In one embodiment, the ratio is calculated by comparing the binding affinity of the anti-pSer413 tau antibodies to a phosphorylated peptide such as SEQ-ID-NO:8 to the binding affinity to the non-phosphorylated peptide of SEQ-ID-NO:69.
SEQ-ID-NO:8) is compared to binding to non-phosphorylated peptides (e.g.
Table 4B: ELISA analysis of reactivity with non-phosphorylated peptide PD17
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